According to the Wine Application Database Version 4.5 works well with the development version 2.5 of wine. Instruction on how to obtain and install this version is available here.
In a nutshell, the steps are as follows:
If you have previously installed a Wine package from another repository, please remove it and any packages that depend on it (e.g., wine-mono, wine-gecko, winetricks) before attempting to install the WineHQ packages, as they may cause dependency conflicts.
Your system will require Multiarch support
Add the repository:
sudo apt-key add Release.key
sudo apt-add-repository https://dl.winehq.org/wine-builds/ubuntu/
Update packages and install:
sudo apt-get update && sudo apt-get install --install-recommends winehq-devel
You will notice some differences between the distro packages and the winehq builds. For more on this see the details.
According to winehq Ubuntu Multiarch support is still incomplete, so there may be further hoops to jump through that I am unable to test at present. The most current information I could find on this topic can be found here
dpkg: How to remove a package and all other packages depend on it?