I have been banging my head against a wall for a couple days on this...I have read through several forums...etc. and nothing has worked. My machine is a Dell Optiplex 330 which originally ran Windows 10 and the wake from USB keyboard/mouse worked fine. Now, I can't seem to get my computer to wakeup from suspend with my keyboard and/or mouse no matter what I do. Any thoughts?
I've experienced this before albeit rarely.
Try plugging in a ps/2 keyboard and/or mouse to see if this solves your problem.
Some mobos have issues with USB ports "going to sleep".
Also, reboot, go into the BIOS and check that the USB port(s) you are using for your kybd/mouse are fully active. BIOS use different features and nomenclatures to describe this. Look for the pull down choice that is least likely to allow the USB ports to go to sleep.
Somehow after days of searching and trying...I found this site after posting my question and it worked like a charm! http://bernaerts.dyndns.org/linux/74-ubuntu/220-ubuntu-resume-usb-hid