I recently did a backup of my ZNC VPS, and did a clean install from 14.04.5 to 16.04.1 Server. The only major issue that I'm having so far, is moving from init.d to Systemd. ZNC just won't autoboot.
Things I've tried so far,
I've run everything under my user as sudo and still, it exits when called on and will not start automatically upon reboot. Starting ZNC manually however works fine.