It seems that this problem is specific to Ubuntu and not Gnome 3 itself, that's why I'm not posting it on SuperUser but here.
I installed at least 3 instances of Ubuntu Oneiric Ocelot (11.10) on different hardware lately, all intended to work with gnome-shell (Gnome 3) as default Desktop environment.
On two of these system the default shortcut of Alt+F2 did not work from the beginning. I had to configure it over the System Settings > Keyboard > Shortcuts under System > Show the command prompt to make it work. But on the system where it worked, the shortcut in this window was not visibly configured.
Also I wanted to configure Win+e to open my Home folder with Nautilus and Win+w to open a gnome-terminal. I configured this on the Launchers menu, it then showed Mod4+W and Mod4+E now accordingly. Note that the W and E are upper case, don't know if this is relevant.
The shortcut to open a terminal works in most of the cases, although in some rare cases I can't get it to open the terminal, no matter how often I press the button. This is clearly not the meaning of a global hotkey.
Even worse: The shortcut to open my Home folder almost never works. If I'm in a textbox in Firefox for example, I see the cursor blinking up when pressing, but nothing happens. If the Desktop is on focus, for pressing Win+e I get a little textbox in the lower right showing an e as if selecting a file in Nautilus by simply typing while in focus. But the problem exists also outside of textboxes. In most of the cases it helps to hammer it multiple times but then most of the times multiple instances of Nautilus open up. This is clearly not useful.
What is it with the global hotkeys? Those things did always make problems for me, already in lower versions of Ubuntu and in Gnome 2. Now it seems to be out of control completely. What components are responsible for handling this? What can I do to make this work smoothly all the time and on all installations?