This question already has an answer here:
I want to run some windows applications under Wine/PlayOnLinux. let's say they are infected or they have some malicious behavior.
Is it safe to create another user account and run these program under Wine with that account?
-- Edit --
My question is more related to the user accounts.
What if i run this malicious software with another user account which is not an admin (can't run sudo) and has no access to anywhere else except its own home directory.
So, in this scenario are my personal files at my primary account safe? is the ubuntu root ( / ) partition safe and untouchable? i think it should be.
According to this link running wine as a separate user is a good thing to do.
But what about the removal devices or mounted ntfs partitions? i think their not the case and can be infected easly.