If you know which device wake up your PC go to first step to follow the guide. If you don't, then open terminal and do:
cat /var/log/syslog
And find which device is waking your PC.
So now:
hit in terminal:
grep . /sys/bus/usb/devices/*/power/wakeup
To list all usb ports that wakeup our pc.
sudo su
we have now root privillages.
2.I have 8 USB ports and in this example let's say that I want to disable usb8 ,so:
echo disabled > /sys/bus/usb/devices/usb8/power/wakeup
Go ahead and test it. Now that specific device in USB port 8 won't wake up the PC.
Next step, to make the change permanent after each boot:
3.
sudo nano /etc/rc.local
And we paste the command from step 2. In there (before the exit 0 of course).
That's it.
optional Only if after sleep/wakeup process the USB 8 device , in my example , revert back to enabled.
- Write a
udev
rule too to execute the command after every boot,sleep,wake up.
Open a terminal and do:
lsusb
At your keyboard device id information the 4 first digits are the vendor id and the 4 next digits are the product id 
Next do:
sudo nano /etc/udev/rules.d/10-wakeup.rules
Where "wakeup" enter your desired name of the script. Number 10 is the priority in case you have many other udev rules, the lower the number the 'rule' will be executed before the others.
Copy paste this and replace the vendor id and product id with your own wireless keyboard vendor id and product id.
ACTION=="add", SUBSYSTEM=="usb", ATTRS{idVendor}=="062a", ATTRS{idProduct}=="4101" RUN+="/bin/sh -c 'echo disabled > /sys/bus/usb/devices/usb8/power/wakeup'"
*usb8 for me is my wireless keyboard (you can also see that in the screenshot (Bus 008)), replace it with your own.
Ctrl + O to save , Ctrl + X to exit and reboot.