I had this same problem. I found a work around that is not really practical. (I am using Intel i7 + good HD screen.) Normally I use hint full, antialias ticked.
When Quetzal was released I installed a new Precise and updated to Quetzal without any modifications, except disable overlay scroll bars and global menu. Then installed xfce from repository. (I did not install the whole xubuntu-desktop until I had all this sorted.)
At first xfce was OK except the default colors were a bit bland. After I jiggled with settings > Appearance and Window manager I opened a new Firefox window. The menu was good, but the page and toolbars were rainbows. But this was only in Firefox.
On the same screen at the same time were other applications which rendered perfectly. (Synaptic and Appearance).
By changing font settings and opening new windows of Firefox after each, I established that Firefox does not respond to antialias or hinting in the currently exposed background or foreground windows.
I could set hinting none, antialias none, and see the very blocky fonts in most applications on the screen. But perfect fonts in Firefox.
I decided that at some point in user space Firefox was getting antialias and hint applied twice on the same page.
My temporary solution was to open a new account with admin privilege, and put up with the bland theme till this is sorted. (Or keep my old partition.)
PS. I have noticed that not all themes are setup to be good for gtk2 and gtk3. So applying a theme in appearances or window manager is sometimes hit an miss. You change theme A to theme B then going back to theme A is different to what it was moments ago. Settings are not being cleaned up between themes.