This is not duplicate of Ubuntu 18.04 Static IP with NetPlan require reboot I tried with both renderers with no lack. Changes are applied only after reboot. I tried ifup/ifdown/netplan apply. Nothing works. Fresh installation of Ubuntu 18.04 LTS on physical hardware. network-manager was not installed by default. I installed to test both renderers. I changed settings and used networkd as renderer. Changed again and used NetworkManager as renderer. After reboot latest changes are applied. Server has 2 raid controllers and it takes looong to reboot. According to documentation reboot is not needed. Any clue?