I tried to run 11.10 on my desktop, and couldn't get Orca screen reader to read desktop screen without using the mouse. My wife is totally blind and has trouble using the mouse to find icons.
Switched back to 11.04 with classic Gnome desktop for which Orca works fine. She just has to right-click with the mouse and Orca works great after that, but this doesn't work with 11.10. Is it going to work in 12.04 when it comes out. I would like to upgrade but can't unless we can get a screen reader that will work right.