From cyberciti:
The usb-storage.ko is the USB Mass Storage driver for Linux operating system. You can see the file typing the following command:
ls -l /lib/modules/$(uname -r)/kernel/drivers/usb/storage/usb-storage.ko
All you have to do is disable or remove the usb-storage.ko driver to restrict to use USB devices on Linux such as:
- USB keyboards
- USB mice
- USB pen drive
- USB hard disk
- Other USB block storage
BIOS option
You can also disable USB from system BIOS configuration option. Make sure BIOS is password protected. This is recommended option so that nobody can boot it from USB.
Grub option
You can get rid of all USB devices by disabling kernel support for USB via GRUB. Open grub.conf or menu.lst and append "nousb" to the kernel line as follows (taken from RHEL 5.x):
kernel /vmlinuz-2.6.18-128.1.1.el5 ro root=LABEL=/ console=tty0 console=ttyS1,19200n8 nousb
Make sure you remove any other reference to usb-storage in the grub or grub2 config files. Save and close the file. Once done just reboot the system:
reboot
Hope this helps.