If you tried pipelight without success do this:
sudo pipelight-plugin --disable-all
sudo rm /usr/lib/mozilla/plugins/libpipelight.so
pipelight-plugin --disable-all
In my case the problem was related to hardware acceleration. Running netflix desktop using the command below worked for me:
wine-browser --disable-hw-acceleration
If the above works for you you can make changes to the launcher that will stick until the next update to netflix-desktop by issuing the following commands:
sudo mv /usr/share/wine-browser-installer/hw-accel-default /usr/share/wine-browser-installer/hw-accel-default2
echo -e '#!/bin/sh\nexit 1;' | sudo tee /usr/share/wine-browser-installer/hw-accel-default
sudo chmod +x /usr/share/wine-browser-installer/hw-accel-default
Source: https://answers.launchpad.net/netflix-desktop/+question/237615