I've got a Toshiba a505 laptop and tried the live CD with great results.
However, I haven't found any reports on this PC working 100% OK on Ubuntu 10.10 yet. I do have seen (and tried installing myself) some reports that 10.04 didn't work (without some dirty hacking).
In regular circumstances, is it OK to assume that a new install will work if the live CD works? Are there any tools I can run to check compatibility?