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I have heard about programs like Wine that allow Ubuntu users to run .exe files.

Which program should I use, and how should I use it?

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marked as duplicate by belacqua, Mateo, Eric Carvalho, Basharat Sialvi, Radu Rădeanu Jun 9 '13 at 5:51

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Wine allows you to execute a .exe program if you select Wine as a default program for .exe files from Nautilus, open a .exe file using "Open with another application" and select Wine or you execute wine file.exe from terminal.

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Files do not need to have the executable bit set to be runnable from Wine. Also, the correct command would be chmod +x file.exe to set the executable bit, not -x. –  dobey Jun 8 '13 at 23:56
You're right, I'll edit. –  Leo Jun 9 '13 at 7:58

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