I'm all for using default shortcuts for basic task — you'll avoid conflict and know the default keys when using another Ubuntu computer.
One exception is the minimize window keyboard shortcut: Ctrl+Alt+0. This only works with numpad zero (not wise for an OS optimized for netbooks) and not for me as I don't have a numpad.
Whenever I set a custom shortcut either via keyboard settings or dconf they only last one reboot.
The only answer I found involves completely resetting Unity which I would very much like to avoid as I have a lot of custom settings — and I don't even know if it works for 12.10.
Does anyone have a solution for this?