I have a Toshiba Satellite P755-S5391, and I installed Ubuntu 12.04 on it, worked like a charm without any modifications.
That was some time ago, and I was hesitant to switch to 12.10 because I heard that it wasn't as stable as 12.04 LTS, but I saw a review online claiming it was more stable than 12.04, so I figured I'd go for the upgrade.
After booting into 12.10, my audio, wireless card, and touch pad all stopped working. I was just wondering, how does this make sense? Why would an update remove drivers that made my system work? (I'm assuming that's what happened.) Maybe the update didn't download everything correctly, or I should try a clean install of 12.10? The strange thing is, I was able to get the wireless to work during the install of 12.10, and I know it's not the wifi being disabled because of function+f8, because that works on my 12.04 and windows 8 installations.