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When I try to run an .exe file, nothing happens. If I right-click it, the "open with Wine" option doesn't show up. If I go to "open with..." Wine doesn't show up either. If I try to open from terminal I get

cd Directory\with\application.exe
wine application
wine: cannot find L"C:\\windows\\system32\\application.exe"

I've tried reinstalling wine and still getting the same results. I'm using Ubuntu 12.10 with Wine 1.5.22 Please any ideas?

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is application.exe actually supposed to be in c:\windows\system32 ? –  ImaginaryRobots Jan 24 '13 at 19:00
No, it's not. It's in my home folder –  Zqrump Jan 24 '13 at 22:36
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