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This comes up sometimes when I attempt to check for updates. I have been trying to upgrade from 12.04 to 12.10, but I have been unsuccessful, due to the fact that Update Manager is not giving me the option to upgrade.

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Do you use a proxy server for internet connection? – Hashken Dec 11 '12 at 3:09
sudo rm -rf /var/lib/apt/lists/* 
sudo apt-get update 

alternately you can go into Software Center and select Software Sources, select Other Software and remove the conflicting ppa's.

The first option worked on a friends system when he couldn't update his system. Option 2 i recently did when I started constantly having issues with being unresponsive. Hope this was some what helpful

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