I'm having the same problem with an Epson GT-1500 and I've found a solution which works, although not the best solution.
I had to install special epson drivers for my scanner into my chroot area for the clients
(Refer: http://download.ebz.epson.net/dsc/search/01/search/?OSC=LX)
Downloaded my drivers, copied them into my chroot section and installed with the following commands:
sudo apt-get install xsltproc
sudo dpkg -i iscan*
Once I had that installed I had to rebuild my ltsp image, reboot the client, then once the client was up I had to replug the scanner in. Then I could start simple scan locally and it would work.
ltsp-localapp simple-scan
Make sure you scanner is coming up on the client
ltsp-localapp xterm
Then within xterm
sane-find-scanner
You should see your scanner in here.