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I know I can use xset m 3 1 to change the sensitivity of the mouse but when I turn off my computer it will go back to normal. Any way to prevent this?

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up vote 1 down vote accepted

You will need to modify /etc/X11/xorg.conf to make it permanant.
There should already be settings for mice in there (see below), you would just need to change the acceleration options.

Section "InputClass"
    Identifier "My Mouse"
    MatchIsPointer "yes"
    Option "AccelerationNumerator" "1"
    Option "AccelerationDenominator" "1"
    Option "AccelerationThreshold" "0"

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