I have a Toshiba L650, installed (dual boot) Ubuntu 10.10. Touchpad worked fine until I tried for the first time to suspend (I closed the screen on the keyboard).
The system never woke up again. Reset (battery disconnected and then reconnected), restart of the system, disk checks, and so on.
After that, everything works fine except the Touchpad, completely dead. Rebooted again. The problem persists.