and if I can how?
I'm using Gnome Shell If that matters
Yes you can. All you need to is backup any files you may need, then run the following:
rm -rf ~/*
If you still have files in your home folder, you can run Nautilus as root:
gksu nautilus
then navigate to your home folder, unhide all hidden files (ctrl+H) and select and delete them.
After this, log out and log back in, or restart your computer.