Ctrl+Alt+T assigned as my keyboard shortcut to launch a Terminal window, but it stopped working after upgrading to 12.10.
I have verified that it is still set in the Keyboard Shortcuts settings menu, and have verified that other shortcuts (e.g. Ctrl+Alt+C to open calculator) work.
I have also tried using assigning different key combinations to Terminal, to see if that helps (it doesn't), e.g. unassigning Ctrl+Alt+C from calculator, and instead assigning it to Terminal. No dice.
Any ideas what might be going on?