My purchase of the Asus USB-N53 just came in today and I spent several hours Googling and researching drivers for this device. When I first plugged the device in it connected fine to my open system, WEP, DHCP configured access point. I opened Google Chrome and a few pages loaded, everything seemed fine. 30 seconds later... Boom! It disconnected and showed attempts to reconnect and asked for the WEP key and just showed a state of infinite connection time until it asked me for the password again. I'm using amd64 (64 bit Ubuntu desktop 12.04 LTS)
The official driver can be found here although I had no luck with it.
Bus 003 Device 002: ID 0b05:179d ASUSTek Computer, Inc.
Linux Jake 3.2.0-31-generic #50-Ubuntu SMP Fri Sep 7 16:16:45 UTC 2012 x86_64 x86_64 x86_64 GNU/Linux