When I upgraded to Ubuntu 12.4 on my HP 32-bit Pavilion, from time to time my cursor goes berserk. Completely beyond my control, it zaps all over my workspace, homing in on clickable targets and clicking on them, wreaking havoc, opening and closing and activating at random.
In addition to the programs that came with the Ubuntu distro, I have a number of programs related to my occupation (technical editor, writer, and illustrator): ClamTk, pyrenamer, Comix, Fontmatrix, GIMP 2.8, Inkscape, KColorChooser, Calibre, Sigil, Kompozer, Audacious, Audacity, K3b, and VLC player.
I also futzed with the theme because I didn't like the black and orange one (I like blue). I wiped my drive and re-installed to no avail. I searched the web and forums and no one seems to be having this problem.