I am currently experimenting with using Ubuntu as a my main OS instead of Windows 7. So far, pretty much everything is working fine, except for an issue that I am having with my touchpad.
I have a Dell XPS 16 (1640) with a Synaptics touchpad. It works out of the box, but it seems that it stops working after returning from hibernation mode.
This problem has also been addressed in an earlier bug: https://bugs.launchpad.net/ubuntu/+source/linux/+bug/317270 but judging from this bug report, it should be fixed by now.
I am running the 2.6.35-23-generic-pae kernel.