There is a lot of talk about bits wearing out but that refers to older models. The existing SSDs will out live the life of the computer. So how you set it up is not that relevant, at least in my experiance.
I have been using a SSD in two ways.
My main computer is running with Ubuntu 12.10, started with 12.04 have been running now about a year. I use my computer 8-10 hours a day, download lots of stuff and haven't struck any issues at all. It's only a 64gig SSD and use my main hard disk which is 2 terabytes for all of my data.
I also use another SSD that is plugged into the computer via an external hard disk adapter that runs Windows 7. When I boot off that the other drive which I formatted as NTFS so both Linux and Windows can access it without any issues.
The only issue you will run into with NTFS partitions is that you cannot make a file executable. So if you have scripts and need to run them while using Linux you have to run them through the bash command.
The biggest descision will be the brand of SSD you purchase. There are some bad SSDs out there so do your research, and dont belive everything you read. My SSD was an Intel and another brand I use was not as good, but still works.